Research Links
DARPA Restorative Injury Repair:
http://www.darpa.mil/dso/thrusts/bio/restbio_tech/rir/index.htm
Restorative Injury Repair
Program Manager: Dr. Jon Mogford
The vision for the Restorative Injury Repair (RIR) Program is to fully restore the function of complex tissue (muscle, nerves, skin, etc.) after traumatic injury on the battlefield. These injuries include both kinetic (i.e., penetrating wounds) as well as other destructive injuries (chemical and thermal burns, musculoskeletal injuries, blast overpressure, etc.). RIR aims to replace the current concepts of "wound coverage" by fibrosis and scarring with true "wound healing" by regeneration of fully differentiated, functional tissue.
The program will achieve its goals by developing a comprehensive understanding of the wound environment, including cellular elements, matrix, inflammatory mediators, growth factors, nutrients, substrate utilization, biofilms, and ultimately processes of morphogenesis leading to anatomic and functional restoration. This is an extremely aggressive, milestone-driven program, with a Phase 1 effort focused on defining the wound environment and generating a blastema in an otherwise non-regenerating animal. This will be followed by a Phase 2 effort, which will culminate in the restoration of a functional multi-tissue structure in a mammal.
| DARPA Restorative Injury Repair: | ||
|---|---|---|
| Program Manager: Dr. Jon Mogford | abstract | |
| http://www.darpa.mil/dso/thrusts/bio/restbio_tech/rir/index.htm | ||
| National Center for Rehabilitative Auditory Research (NCRAR) | ||
| Talk on blast trauma: Director's Meeting for VA Centers of Excellence in Rehabilitiaton Research and Development, Portland | ||
| Dr. Lew | abstract | |
| http://www.vard.org/jour/05/42/4/pdf/lew.pdf | ||
| Therapeutic interventions after spinal cord injury: Nature Reviews, Aug, 2006 | ||
| Thuret, Moon & Gage, authors | abstract | |
| http://www.nature.com/nrn/journal/v7/n8/full/nrn1955.html | ||
| Future Related Conferences: | ||
| 5th Annual Battlefield Healthcare | ||
| IDGA | ||
| http://www.idga.org/cgi-bin/templates/singlecell.html?topic=221&event=11985 | ||
| Bleeding in Massive Trauma - Information Packet | ||
| Leo R. Zacharski Download Doc ; | ||
| Burn Unit -Brigham and Women's Hospital | ||
| Dennis P. Orgill, M.D., Ph.D. | ||
| http://www.brighamandwomens.org/surgery/research/facultypages/orgillresearch.asp | ||
| http://burnsurgery.org/ | ||
| http://www.idga.org/cgi-bin/templates/singlecell.html?topic=221&event=11985 | ||
| Preventing brain injuries in war - why standard-issue helmets weren't enough | ||
| Matthew B McCoy Download Doc ; | ||